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URN etd-0105109-150800 Statistics This thesis had been viewed 3164 times. Download 4619 times. Author Yao-Chung Chang Author's Email Address email@example.com Department Bioengineering Year 2008 Semester 1 Degree Master Type of Document Master's Thesis Language zh-TW.Big5 Chinese Page Count 80 Title Extraction of glucosamine derivatives and the applications on the
modification of biomedical materials
Keyword modification chitosan chitosan modification Abstract This thesis developed the extraction methods for extracting glucosamine from
animal by products. Hyaluronic acid was extracted from the comb of roosters. The goal is
to enhance production rate as well as the purity of hyaluronic acid. The production rate of
hyaluronic acid was 0.50% for the first extraction, 0.63% for the second extraction, and
0.13% for the third extraction. HPLC was used to determine the purity of the hyaluronic
acid. Chitin and chitosan from shrimp shell was another source of glucosamine. The
production yield was 6.91% when extracted with alkaline solution. Chondroitin from pig
ears and pig trachea was obtained with acetic acid extraction process. The production
yield from pig ears is 7.15% while the production yield from pig trachea is .07%.
The glucosamines obtained from animal were used in modification experiments. We
used the Plasma treatment method to graft glucosamine onto different materials, including
pHBV membrane and sutures. The cell proliferation and adherence of pHBV
（poly(3-hydroxybutyrate-co-3-hydroxyvalerate)）membrane also can be further
improved by plasma treatment. Biodegradable sutures, Polyglactin, grafted with chitosan
were tested to determine it’s properties. The results indicate that modified sutures has
better antiseptic property than unmodified sutures.
Advisor Committee Chung-Yih Wang - advisor
Files Date of Defense 2008-12-05 Date of Submission 2009-01-05