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URN etd-0128115-212111 Statistics This thesis had been viewed 1879 times. Download 270 times. Author Chun-Hsuan Peng Author's Email Address email@example.com Department Materials Engineering Year 2014 Semester 1 Degree Master Type of Document Master's Thesis Language zh-TW.Big5 Chinese Page Count 72 Title Development of pH-Sensitive Water-Soluble Chitosan/Hyaluronic Acid Nano-Carriers for Oral Drug Delivery Keyword Nanoparticles pH sensitive drug delivery carrier drug delivery carrier pH sensitive Nanoparticles Abstract Drug delivery technology is order to effectively increase drug utilization and reduce its side effects. Among them, the oral mode of administration for the patient received wide. However, when the drugs are used orally, through the stomach (pH1.2) digestion of drugs and denaturation or degradation, making the drugs can not be absorbed in the small intestine conduct, and therefore can not achieve the intended therapeutic effect. This study will use chitosan (Chitosan, CS) of the water-soluble derivative of carboxymethyl chitosan (N, O-carboxymethyl chitosan, NOCC) and hyaluronic acid (hyaluronic acid, HA), cross-linked by the ion way to prepare pH sensitive issue nanoparticles. In the FTIR and NMR results showed success in chitosan glucosamine units of the amino and primary hydroxyl modified with carboxymethyl chitosan, increasing its water solubility and its application. DLS and TEM results shows that using different types of ions associated physical intercourse prepared NOCC-HA nanoparticles, as the pH changes in the environment by the pH 1.2-7.4, the average particle size(200nm~500nm) may vary. Meanwhile, NOCC-HA ionic crosslinking of the pH-sensitive nanoparticles to the surface of the average potential(+23~-33ev) carried by the positive to negative electricity. The release curve was shown that these nanoparticles were able to sustain the release of drug under simulated colonic conditions. Cell viability study suggested that the nanoparticles had good biocompatibility, and particle can delivery drug facilitated uptake by cell. In this study, a new nanoparticle system, a simple coacervation method. These are applied to a wide range of potential biomedical oral drug delivery vector systems. Advisor Committee Hsi-Chin Wu - advisor
Ping-Shan Lai - co-chair
Files Date of Defense 2014-12-22 Date of Submission 2015-01-28