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The defense date of the thesis is 2014-02-11
The current date is 2020-01-18
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URN etd-0210114-145712 Statistics This thesis had been viewed 1290 times. Download 0 times. Author Jie-Yi Jiang Author's Email Address email@example.com Department Bioengineering Year 2013 Semester 1 Degree Master Type of Document Master's Thesis Language zh-TW.Big5 Chinese Page Count 80 Title RESPIMATR INHALER DELIVERY SYSTEM FOR INHALATION THERAPY IN MECHANICALLY VENTILATED,IN VITRO Keyword Chronic obstructive lung disease drug delivery Tiotropium Respimat inhaler Respimat inhaler Tiotropium drug delivery Chronic obstructive lung disease Abstract Respimat R inhaler equipped with Tiotropium bromide, which is a long-acting anticholinergic agent. According to 2013 Global Initiative for Chronic Obstructive Pulmonary Disease Organization（GOLD) treatment standards, long-term anticholinergic tiotropium can selectively inhibit M3 and M1 receptors. The duration of action of Tiotropium is more than 24 hours,which can reduce the probability of COPD exacerbations and hospitalizations, improve symptoms and health status, and increase the effectiveness of pulmonary rehabilitation.
If Respimat R inhaler can properly connect to a mechanical ventilator to deliver drugs for patients with respiratory failure, it will improve the quality of care. This study designed a method to connect the inhaler to ventilator to improve the deliver of drug into lung. The delivery amount of drug was analyzed with High Performance Liquid Chromatography.
Advisor Committee Chung-Yih Wang - advisor
Dey-Chyi Sheu - co-chair
Ming-Chou Chiang - co-chair
Files Date of Defense 2014-01-06 Date of Submission 2014-02-11