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Title page for etd-0216116-110124


URN etd-0216116-110124 Statistics This thesis had been viewed 666 times. Download 0 times.
Author Kai-yuan Gu
Author's Email Address No Public.
Department Bioengineering
Year 2015 Semester 1
Degree Master Type of Document Master's Thesis
Language zh-TW.Big5 Chinese Page Count 77
Title Preparation and Characterization of Thermosensitive Nano-Hydrogel for The Tumor Hyperthermia
Keyword
  • N-vinyl-2-pyrrolidone
  • N-isopropylacrylamide
  • methacrylic acid
  • nano-hydrogel
  • thermosensitive nano-hydrogel
  • gold nanoparticle
  • gold nanoparticle
  • thermosensitive nano-hydrogel
  • nano-hydrogel
  • methacrylic acid
  • N-isopropylacrylamide
  • N-vinyl-2-pyrrolidone
  • Abstract Hydrogels are polymers that can water swelling. In recent years, hydrogels and hydrogel nanoparticle have found in a variety of biomedical applications, including drug delivery and cancer treatment. The aim of this study is to prepare a NIR-responsive thermosensitive nano-hydrogel for the tumor treatment by hyperthermia. Firstly, we used N-isopropylacrylamide (NIPAAm) and glycidyl methacrylate (GMA) to synthesize a nano-hydrogel with its particle size between 100 nm and 300 nm by ultraviolet (UV) light. And its lower critical solution temperature (LCST) was between 33 and 35C. We attempted to synthesize another nano- hydrogel with higher LCST by introducing more hydrophilic monomers, N-vinyl-2-pyrrolidone (VP) and methacrylic acid (MAA), into poly(N-isopropylacrylamide) (PNIPAAm) polymer. The thermosensitive nano-hydrogel was synthesized and its LCST was about 40C. Thereafter, the synthesized chemically gold nanoparticle was modified by mercaptoundecanoic acid (MUA) before plasma treatment, and then it was grafted by NIPAAm, MAA, and VP by UV-induced free radical polymerization. The gold nanoparticle-grafted thermosensitive nano-hydrogel was successfully synthesized without cytotoxicity.
    Advisor Committee
  • Ming-tse Lin - advisor
  • Dey-chyi Sheu - co-chair
  • Yi-chien He - co-chair
  • Files indicate not accessible
    Date of Defense 2016-01-29 Date of Submission 2016-02-16


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