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URN etd-0304105-150948 Statistics This thesis had been viewed 3804 times. Download 1146 times. Author Chih-hsien Chang Author's Email Address firstname.lastname@example.org Department Materials Engineering Year 2004 Semester 1 Degree Master Type of Document Master's Thesis Language English Page Count 156 Title Surface Modification of ePTFE Film by Cold Plasma/Photo-grafting and Subsequent Immobilization of Condroitin-6-Sulphate Keyword surface modification Polyterafluoroethylene(PTFE) grafting polymerization Expanded polyterafluoroethylene(ePTFE) cold plasma Chondroitin-6-sulfate biomaterials biomaterials Chondroitin-6-sulfate cold plasma Expanded polyterafluoroethylene(ePTFE) grafting polymerization Polyterafluoroethylene(PTFE) surface modification Abstract Expanded polytetrafluoroethylene (ePTFE) film is a kind of surface hydrophobic materials. To improve the surface hydrophilicity and biocompatibility of ePTFE film, cold plasma treatment, UV graft polymerization and subsequently immobilization of condroitin-6-Sulphate are used in this study.
For the hydrophilic modification of expanded ePTFE films, argon (Ar)
plasma treatment is carried out in order to create active site and free radicals on the surface of ePTFE films, the optimal condition is 50w/10min, 200mtorr and subsequently UV graft polymerization with different hydrophilic monomers and introduce hydrophilic functional groups like C=O, C-O, COOH and NH2. In this study, ePTFE surface can be grafted with different monomers (AAm, AAc, NIPAAM and NVP) successfully. Especially, when ePTFE film is grafted with NVP (80.97mmol, adding APS and TEMED/50min), the hydrophilicity can be improved from 125。to 8。 obviously. But aging effect of surface hydrophilicity modified by plasma treatment and graft polymerization will occur with increasing storage time. Using chemically cross-linking method with cross-linking agent, EDC (5w%) can immobilize the biocompatible polymer, condroitin-6-Sulphate (10wt%) on ePTFE-g-AAc(41.63mmol/20min) films successfully, it was expected to be used as biomaterials.
Advisor Committee Ko-Shao Chen - advisor
Chi-Yuan Huang - co-chair
Hong-Ru Lin - co-chair
Files Date of Defense 2005-01-28 Date of Submission 2005-03-04