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URN etd-0624108-030053 Statistics This thesis had been viewed 2261 times. Download 1145 times. Author Jeng-Ting Pan Author's Email Address No Public. Department Mechanical Engineering Year 2007 Semester 2 Degree Master Type of Document Master's Thesis Language zh-TW.Big5 Chinese Page Count 63 Title The Thermal Analysis and Optimization Arrangement of Multiprobe in Prostate Cryosurgery Keyword cryosurgeryr bioheat equation tumor prostate prostate tumor bioheat equation cryosurgeryr Abstract Cryosurgery has been found in several areas of application, including treatment of cancerous prostate growth, kidney cancer, and lung cancer etc. Because the size of the prostate tumor is usually greater than the diameter of cryoprobe, it must use multiprobe to perform a cryosurgery at the same time. The doctor uses ultrasound, CT, or MRI to guide the cryoprobe and monitor the size of the ice ball.
The present study is to exactly split the target region and the surrounding healthy tissue in the detective area. Also, the target region can be maintained below -20 ℃.Hence, in this research, an optimization method is introduced to find the optimal location of multi-cryoprobes, while a bioheat transfer simulation is used to predict the temperature distribution that would result from the current configuration of the cryoprobes during iteration. The 2-D numerical method combine optimization techniques with bioheat transfer simulation will be used to determine the best location of cryoprobes. After combining bioheat transfer simulation with numerical optimization technique in this research, the optimal location of cryoprobes will be found on different 2-D geometries. The latent heat of fusion should be incorporated into bioheat transfer model during the occurrence of the phase change in tissue. In addition, the -20 ℃ isotherm has been distinguished in the present study to supply for the reference of a real cryosurgery. It is believed that the results from this research can supply valuable data to the clinician for the reference of a real cryosurgery in the future.
Advisor Committee Hong-Sen Kou - advisor
Files Date of Defense 2008-05-27 Date of Submission 2008-06-29