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The defense date of the thesis is 2011-07-01
The current date is 2019-05-22
URN etd-0701111-110839 Statistics This thesis had been viewed 1808 times. Download 0 times. Author HSUAN-YI PAI Author's Email Address No Public. Department Bioengineering Year 2010 Semester 2 Degree Master Type of Document Master's Thesis Language zh-TW.Big5 Chinese Page Count 68 Title Preparation of porous scaffold with collagen coated PCL and its application in the cartilage tissne engineering Keyword polycaprolactone cartilage tissne engineering collagen collagen cartilage tissne engineering polycaprolactone Abstract This research developed the dip-coating technology for tissue engineering scaffold. Porous polycaprolactone (PCL) scaffold was prepared with particulate leaching method. Collagen, a natural biological material, was extracted and deposited on the PCL scaffold with controlled pulling speed. The mechanical strength of the collagen/ PCL composites is similar with PCL. The water contact angle (WCA) for PCL scaffold decreases from 80~90 degrees to 40 ~50 degrees, suggesting the hydrophilic increased markedly after collagen coating.
The collagen/PCL composite prepared without the addition of chemical crosslinkers may provide high biocompatibility. The IRC cells were used to survey the effects of coating on PCL scaffold. After cultured on collagen/ PCL composite for seven day, the cell number reaches maximum. The collagen coating could maintain IRS’s phenotype and increases the attachment of cells on the scaffold, which is suitable for cartilage tissue engineering.
Advisor Committee Chung-Yih Wang - advisor
Sheu, Dey-Chyi - co-chair
Files Date of Defense 2011-06-20 Date of Submission 2011-07-01