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Title page for etd-0712107-121929


URN etd-0712107-121929 Statistics This thesis had been viewed 2221 times. Download 57 times.
Author Shin-Ping Chen
Author's Email Address No Public.
Department Materials Engineering
Year 2006 Semester 2
Degree Master Type of Document Master's Thesis
Language zh-TW.Big5 Chinese Page Count 81
Title Immobilization of Heparin on Engineering Plastic PEEK by Plasma Treatment and Graft Process
Keyword
  • AAm
  • HMDSZ
  • QCM
  • Heparin
  • Graft
  • PECVD
  • PEEK
  • PEEK
  • PECVD
  • Graft
  • Heparin
  • QCM
  • HMDSZ
  • AAm
  • Abstract In this study, the plasma enhanced chemical vapor deposition (PECVD) of hexamethyldisilazane (HMDSZ) was used to obtain a thin adhesive film on the surface of polyetheretherketone (PEEK). The film was subsequently grafted with UV-light induced polymerization of acrylamide (AAm), which can provide useful functional group for immobilizing Heparin to improve biocompatibility. Quartz crystal microbalance (QCM) was used to measure the effect of PEEK surface modification, because the film thickness is too thin to be easily estimated. After plasma deposition of HMDSZ film, the surface of PEEK exhibited hydrophobic feature. After heparin was immobilized as the outer layer of PEEK surface, the measured water contact angle decreased to 29° and the root mean square surface roughness was determined to be 3.8 nm. From micro-IR spectra, heparin was successfully immobilized on the surface of PEEK. According to X-ray photpelectron spectrometer (XPS) analysis, the element sulfur containing 2.1% atomic concentration revealed that heparin was covalently immobilized on PEEK. Frequency shift of 652 Hz detected by QCM was used to determine the amount of immobilized heparin. From the results of fibroblast cell culture, PEEK immobilized with Heparin can indeed promote cell attachment.
    Advisor Committee
  • Ko-Shan Chen - advisor
  • Ching-An Peng - co-chair
  • Tsong-Rong Yan - co-chair
  • Files indicate in-campus access only
    Date of Defense 2007-07-10 Date of Submission 2007-07-12


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