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URN etd-0719105-141905 Statistics This thesis had been viewed 3312 times. Download 1582 times. Author Jui-long Chien Author's Email Address email@example.com Department Materials Engineering Year 2004 Semester 2 Degree Master Type of Document Master's Thesis Language English Page Count 75 Title Acetic Acid Plasma Treatment of PLGA and Nonwoven Fabric for Improving ES-Cell adhesion Keyword stem cell PLGA plasma nonwoven cell adhesion acetic acid acetic acid cell adhesion nonwoven plasma PLGA stem cell Abstract In this study , the polymer film of acetic acid deposited on the substrate such PP-nonwoven、 poly (lactide-co-glycolide)PLGA by plasma polymerization to improve the cell attachment . From the SEM micrographs, it demonstrated that acetic acid plasma film was successfully deposited onto PLGA scaffolds and PPnonwoven. From the FTIR spectrum it could be observed that there were several adsorption peak of acetic acid film appeared or enhanced such as C-C at 1600 cm-1, C-O at 1125 cm-1, C-H at 1424 cm-1, –OH at 3050~3500 cm-1 and C=O at 1700~1720 cm-1 were reduced. From the results of biopsy and cell adhesion, ES-cell adhesion and proliferate on the modification scaffolds is better than control. The results of water contact angle showed that the surface of acetic acid plasma treated materals were more hydrophilic. The water contact angle of PET film after acetic acid plasma treated was reduced (aap：67° to 7°). After long-term aging time, the PET film after acetic acid plasma treated still keep hydrophilic. In addition, the biocompatibility test demonstrated that ES stem cell may attach and proliferate on modified scaffolds, and it further reveals that acetic acid plasma coated is an effective treatment for improvement of
stem cell adhesion on different substrates.
Advisor Committee Ko-Shao Chen - advisor
Chi-Yuan Huang - co-chair
Hong-Ru Lin - co-chair
Files Date of Defense 2005-07-08 Date of Submission 2005-07-19