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Title page for etd-0724113-154501


URN etd-0724113-154501 Statistics This thesis had been viewed 1875 times. Download 620 times.
Author chia-hui chang
Author's Email Address No Public.
Department Bioengineering
Year 2012 Semester 2
Degree Master Type of Document Master's Thesis
Language zh-TW.Big5 Chinese Page Count 143
Title Preparation of Poly-hydroxy-butyrate-co-hydroxyalerate (PHBV) / Poly-ε-caprolactone (PCL) Membrane by Electrospinning for Tissue Engineering
Keyword
  • Tissue engineering
  • plasma modification
  • electrospinning
  • cell compatibility
  • cell compatibility
  • electrospinning
  • plasma modification
  • Tissue engineering
  • Abstract Abstract
    In recent years, development of tissue engineering becomes an important issue.Cartilage defects caused by trauma or disease are difficult to recover because articular cartilage can’t regenerate by itself . Although allogeneic cartilage has been used , it may lead to rejection, cell death or the loss of function. Therefore, cartilage tissue with synthetic scaffold and autologous cells becomes important research directions.
    This study used electrospinning method to prepare scaffold for cartilage engineering. Biodegradable poly-hydroxybutyrate-co-hydroxyvalerate (PHBV) and polymer material poly-ε-caprolactone (PCL) was chosen as the raw materials. We adjust PHBV content to improve the mechanical properties and degradation rates of the PCL. Polymers blended with different proportion of PHBV/PCL (100/0, 75/25, 50/50, 25/75, 0/100) to form the films. The films were characterized with contact angle measurement, calorimetry (DSC) , Lloyd test machine,and scanning electro microscopy (SEM). PHBV/PCL(50/50) Fiber have the best physical properties, then can be used in plasma modification .To enhance the cell growth rate, we further treated the electropsun fiber with different plasma surface (Oxygen, Hexamethyldisilazane, Oxygen + Hexamethyldisilazane) to modify hydrophilicity of the surface .The results of this study showed that plasma surface modification had improved the cell growth.The hydrophobic fiber had higher growth rate then the hydrophilic fiber.
    Advisor Committee
  • Chung-Yih Wang - advisor
  • Chien-Chung Chen - co-chair
  • Ko-Shao Chen - co-chair
  • Files indicate in-campus access at 2 years and off-campus access at 2 years
    Date of Defense 2013-07-03 Date of Submission 2013-07-25


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