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Title page for etd-0730114-203625


URN etd-0730114-203625 Statistics This thesis had been viewed 1047 times. Download 0 times.
Author Chia-Ti Chang
Author's Email Address No Public.
Department Materials Engineering
Year 2013 Semester 2
Degree Master Type of Document Master's Thesis
Language zh-TW.Big5 Chinese Page Count 159
Title Biocompatibility of Micro-arc Oxidation Titanium Surface Modified by Cold Plasma and Surface Graft Polymerization
Keyword
  • Biocompatibility.
  • Gelatin
  • Chitosan
  • Chondroitin Sulfate
  • Graft Polymerization
  • Plasma
  • Micro-arc Oxidation
  • Micro-arc Oxidation
  • Plasma
  • Graft Polymerization
  • Chondroitin Sulfate
  • Chitosan
  • Gelatin
  • Biocompatibility.
  • Abstract Titanium and its alloy are widely used as scaffolds, bone screw and bone plate. When metal implants in human body, immune system will attack the implant surface. Hence, resistance corrosion and biocompatibility have to be considered. In this study, the micro-arc oxidation used to formation a micro porous ceramic oxide layer film on Ti surface and also to improve the resistance corrosion. We introduced boundary layer by plasma enhanced chemical vapour deposition of hexamethyldisilazane (HMDSZ) organic silicide film and used Oxygen plasma to active this layer for provide free radicals to improve micro-arc oxidation surface’s bioinert. Then grafting polymerization of reactive monomer acrylic acid (AAc) by UV light graft therefore we can immobilize Chondroitin Sulphate, Chitosan or Gelatin on surface by crosslinking EDC/NHS.
      As a result of, the increasing weight of substrates followed increasing micro-are oxidation treatment time. SEM micrographs showed that the coatings of surface becomes densifying after micro-are oxidized 15 min and it becomes smoother after 30min. From FTIR and ESCA, the C-6-S were successful immobilized on specimens. After MAO treated, the water contact angle of titanium sheets surface decrease less than 10° and wear resistance had been improved and all of best is 15min treatment time. Corrosion potential volts also enhanced from -0.4 V to -0.2~-0.3 V. After the plasma treatment, graft polymerization and immobilized different biomolecules on the surface had more effectively its characteristics.
      With micro-arc oxidation time increases, rutile phase decreases and anatase phase increased. Finally in this study 3T3 Fibroblast cell was employed for cell attachment test, the plasma treatment and immobilized biomolecules chondroitin sulfate or gelatin are observed great attachment, the untreated Ti and UV-light grafted AAc were poor, relatively.
    Advisor Committee
  • Ko-Shao Chen - advisor
  • Mu-Rong Yang - co-chair
  • none - co-chair
  • none - co-chair
  • none - co-chair
  • none - co-chair
  • Files indicate in-campus access at 3 years and off-campus access at 5 years
    Date of Defense 2014-07-08 Date of Submission 2014-08-04


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