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URN etd-0806104-171305 Statistics This thesis had been viewed 2810 times. Download 1115 times. Author Yung-Chu Chen Author's Email Address No Public. Department Chemical Engineering Year 2003 Semester 2 Degree Master Type of Document Master's Thesis Language English Page Count 112 Title STUDIES ON PREPARATION AND PROPERTIES OF THE FUNCTIONAL NANOCOMPOSITE HYDROGEL MATERIAL BASED ON ACRYLIC ACID Keyword nanocompositehydrogel hydrotalcite acrylic acid acrylic acid hydrotalcite nanocompositehydrogel Abstract The present part, the influence of the intercalating agent content of 2-acryloylamido-2-methyl propane sulfonic acid (AMPS) in hydrotalcite on the swelling and mechanical properties for the present poly(AA-co-NIPAAm)/IHT nanocomposite hydrogels was investigated. Results showed that the more the content of the AMPS-HT the higher the swelling ratio of the gels and the more the content of the intercalating agent the lower swelling ratio. The gel strength and crosslinking density were not enhanced by adding AMPS-HT into the gel composition, but the maximum effective crosslink density and shear modulus of the nanocomposite hydrogels increased with an increase of the content of the intercalating agent in HT.
The second part, in the previous report, we have reported the effect of intercalating agent content on the swelling and mechanical behavior for poly(AA-co-NIPAAm)/hydrotalcite nanocomposite hydrogels. In this part, the effect of intercalating agent content on the release of various drugs with different charges was further investigated for the Poly(AA-co-NIPAAm)/IHT nanocomposite hydrogels. Results show that the loading amount and release ratio of indomethacin are affected by the swelling ratio in saline solution and related to the affinity in the alcohol solution. The loading amount and release ratio of caffeine is affected by the swelling ratio. The loading amount of crystal violet (CV) increased with an increase of the content of intercalating agent in IHT of the gel but the fractional release of CV in the gels decreases with increase in intercalating agent content. The result of release and loading for phenol red in the hydrogels is contrary to CV.
The third part, a series of novel xerogels based on sodium acrylate (NaA), intercalated hydrotalcite (IHT), and N, N'-methylene-bis-acrylamide (NMBA) were prepared by inverse suspension polymerization. The influences of the intercalated-HT with acrylic acid (AA), the intercalated-HT with 2-acryloylamido-2-methyl propane sulfonic acid (AMPS), and the content of the IHT in the copolymeric gels on the water absorbency and the initial absorption rate in deionized water and various salt solutions were investigated. Results showed that adding a small amount of IHT could effectively increase the water absorbency of the gels, but adding excess IHT could decrease the water absorbency of the gels. In addition, the water absorbency of the gels prepared by AA-IHT was lower than that prepared by AMPS-IHT. The initial absorption rate for the present copolymeric gels increased with increase in the content of IHT in the copolymeric gels.
Advisor Committee Wen-Fu Lee - advisor
Der-Jang Liaw - co-chair
Ko-Shao Chen - co-chair
Files Date of Defense 2004-07-15 Date of Submission 2004-08-06