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Title page for etd-0813107-181404


URN etd-0813107-181404 Statistics This thesis had been viewed 4404 times. Download 8 times.
Author Ci-Zong Zang
Author's Email Address No Public.
Department Bioengineering
Year 2006 Semester 2
Degree Master Type of Document Master's Thesis
Language zh-TW.Big5 Chinese Page Count 94
Title Transdermal Delivery of Arbutin Encapsulated by Ascorbyl Palmitate Liposomes
Keyword
  • liposome
  • encapsulation
  • ascorbyl palmitate
  • transdermal delivery
  • arbutin
  • arbutin
  • transdermal delivery
  • ascorbyl palmitate
  • encapsulation
  • liposome
  • Abstract The aim for the research is to encapsulate arbutin by liposome based on
    non-phospholipids “ascorbyl palmitate”, and then perform transdermal
    delivery experiments by adjusting different factors, such as different drug
    concentrations, encapsulating lipids, surfactants etc. Furthermore, we got the
    physical data, such as permeability coefficients, skin-drug accumulation, and
    so on.
    From the result, we observed that the releasing rate of 5% arbutin
    liposome and 5% non-encapsulated arbutin solution are 19.60nmol/cm2/h
    and 14.79nmol/cm2/h respectively. It means the encapsulation of arbutin has
    enhancing effects for transdermal delivery. By adjusting different drug
    concentration, we observed that releasing rate rises with concentration under
    saturation concentration range. The best formulation is 5% arbutin and it
    comes to the number of 19.60nmol/cm2/h. By adjusting different surfactants,
    DA is the best formulation and it comes to 26.32 nmol/cm2/h. By adjusting
    different lipids, it showed that the lipid did not affect the release.
    In conclusion, the non-phospholipids “ascorbyl palmitate” has effects in
    improving the transdermal delivery efficiency and we could also apply it to
    other drugs to investigate the behaviors for delivery in the future.
    Advisor Committee
  • Chung-Yih Wang - advisor
  • Kow-Jen Duan - advisor
  • Nan-Wei Su - co-chair
  • Files indicate in-campus access at 5 years and off-campus access at 50 years
    Date of Defense 2007-07-19 Date of Submission 2007-08-15


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