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URN etd-0814112-154324 Statistics This thesis had been viewed 1547 times. Download 371 times. Author Chi-han Chen Author's Email Address firstname.lastname@example.org Department Chemical Engineering Year 2011 Semester 2 Degree Master Type of Document Master's Thesis Language Chinese&English Page Count 63 Title Experiments and Data Regression for Two-Dimensional Unsteady-State Temperature Profiles around a Cylindrical Heat Source in an in vitro Tissue Keyword Two-Dimensional vitro Tissue Unsteady-State Temperature Profiles Unsteady-State Temperature Profiles vitro Tissue Two-Dimensional Abstract Thermal therapy is one of the new methods for tumor treatment. This research studies experimentally two possible situations that occur in tumor treatment by thermal therapy, including (a) heat transfer around a cylindrical heat source and (b) heat transfer between a cylindrical heat source and a blood vessel. The research works included (1) experiments in an in vitro tissue where a Ni-Cr wire was used to heat a pork liver and thermocouples were used for temperature measurements; (2) non-liner data regression to determine the parameters in the mathematical model; (3) comparison of temperature profiles between experimental data and model calculations; and (4) study of effect of parameters on average error in temperature profiles.
From heat transfer around a cylindrical heat source it can be found that the temperature increases as it approaches axially or radially the center of the heat source. The axial temperature gradient from the experiment is higher than that from the model calculation, due that the thermocouples provide a pathway for heat transfer from the tissue to the surroundings.
From the contour of average error versus model parameters, it is found that, near optimal value, the effect of parameters on average error is not significant. In other words, small perturbation in parameter estimation does not affect the accuracy of the mathematical model.
The highest tissue temperature reaches 61℃ around a cylindrical heat source, however, it can only reach 56℃ if a blood vessel exists. In addition, for a fixed thermal conductivity, the optimal heat transfer coefficient increases with increasing blood velocity, while the average error is less than 1.6℃.
Advisor Committee Jan-chen Hong - advisor
Jia-ming Chern - co-chair
Xi-zhang Lin - co-chair
Files Date of Defense 2012-07-27 Date of Submission 2012-08-14