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Title page for etd-0816112-143945


URN etd-0816112-143945 Statistics This thesis had been viewed 1334 times. Download 0 times.
Author Niann-Chyi Huang
Author's Email Address No Public.
Department Bioengineering
Year 2011 Semester 2
Degree Master Type of Document Master's Thesis
Language zh-TW.Big5 Chinese Page Count 109
Title EXTRATION OF OSTRICH OIL WITH SUPERCRITICAL FLUID CARBON DIOXIDE TO ENHANCE THE TRANSDERMAL DELIVERY OF PHYTOSPHINGOSINE
Keyword
  • Ostrich oil
  • Supercriticial carbon dioxide extraction
  • Phytosphingosine
  • Phytosphingosine
  • Supercriticial carbon dioxide extraction
  • Ostrich oil
  • Abstract The breeding Taiwan ostrich is mainly for providing meat. The side products such as eggs, feather and skin are also valuable, but the subcutaneous fat was usually abandoned. Ostrich oil is rich in unsaturated fatty acids. Organic solvent extraction or heating method were used to extract ostrich oil from fat. The residual organic solvent and have bad flavor make those methods less popular. In this research, several extraction methods were used to extract ostrich oil. Among those extraction methods, supercriticial carbon dioxide extraction yields the highest amount of unsaturated fatty acids. The condition of 65 ℃ 200 bar have the great yield in small(32 ml extractor) and scale up (100 ml extractor)extraction(74.14±2.07 % and 23.87±1.59 %). The poor solubility in scale up extraction may result in low yield of oil. After deacidification and deodorization, the oleic acid content can reach as high as 30 %.
     The extraction ostrich oil (1 g) was formulated by adding Tween 80 (0.5 g) and Span 60 (0.5 g) and emulsified. Particle size of the ostrich oil cream’s particle size was approximately 600 nm. The capability of increased water content and decreased transepidermal water loss (TEWL) of the epidermis for ostrich oil cream is better than squalane cream. For the transdermal delivery, the permeability coefficient of transdermal delivery for the phytosphingosine encapsulated by ostrich oil cream was 0.32±0.194 cm2/hr, while the permeability coefficient of phytosphingosine which dissolved in ethanol was only 0.246±0.239 cm2/hr. The results suggest that, ostrich oil cream is better than ethanol formula for phytosphingosine transdermal delivery.
    Advisor Committee
  • Chung-Yih Wang - advisor
  • Files indicate in-campus access at 5 years and off-campus not accessible
    Date of Defense 2012-07-13 Date of Submission 2012-08-17


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