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URN etd-0816113-124950 Statistics This thesis had been viewed 828 times. Download 1 times. Author Cheng-Feng Chen Author's Email Address No Public. Department Bioengineering Year 2012 Semester 2 Degree Master Type of Document Master's Thesis Language zh-TW.Big5 Chinese Page Count 105 Title FED-BATCH PRODUCTION AND ECONOMIC EVALUATION OF PHA BY H. MEDITERRANEI Keyword fed-batch Haloferax mediterranei Polyhydroxyalkanoate PHA PHA Polyhydroxyalkanoate Haloferax mediterranei fed-batch Abstract Haloferax mediterranei, an extreme halophilic archaeon, can accumulate polyhydroxyalkanoate (PHA) as intracellular reserve granules. In the present works, in order to reduce the production cost, fed-batch fermentation was performed with feeding medium contained glucose and yeast extract as carbon and nitrogen sources, respectively. The fed-batch process revealed that OD520nm and PHA production could be 99.7 and 9.3 g/L, respectively. Based on this result, an industrial scale production processes was designed and subsequently analyzed to estimate the production cost of PHA. According to the market share of 1328 kilogram per year of high pure PHA, in about 1.03 years of the payback time could achieve. The selling price of the PHA is estimated as $ 2 per gram in comparison with the high price of ordinary medical biodegradable polymers PLGA(Poly(Lactide-co-Glycolide)) which usually sell above the price $ 7 per gram. Therefore PHA has great potential for the medical biomaterial market. Advisor Committee C. Will Chen - advisor
none - co-chair
none - co-chair
Files Date of Defense 2013-07-24 Date of Submission 2013-08-16