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Title page for etd-0820112-223755


URN etd-0820112-223755 Statistics This thesis had been viewed 977 times. Download 0 times.
Author Shun-Yu Hsieh
Author's Email Address No Public.
Department Materials Engineering
Year 2011 Semester 2
Degree Master Type of Document Master's Thesis
Language zh-TW.Big5 Chinese Page Count 86
Title Hyaluronic Acid Modified Magnetic Hydroxyapatite Nanocrystals for Targeted Hyperthermia Cancer Therapy
Keyword
  • hyperthermia
  • target cancer
  • hyaluronic acid
  • magnetic hydroxyapatite
  • magnetic hydroxyapatite
  • hyaluronic acid
  • target cancer
  • hyperthermia
  • Abstract The success of tumor therapy is determined by the efficiency with which the killing of tumor cells is achieved under conditions of no or only slight damage to the normal tissues. Because of its high tumor specificity and biocompatibility, hyaluronic acid (HA) could be potentially used for the design of tumor-targeting marker. HA has been known to interact with the hyaluronan receptor, CD44. HA-CD44 binding triggers intracellular signals that influence cellular proliferation, differentiation, and migration. In this study, HA modified magnetic hydroxyapatite ( HA-modified MHAP) nanocrystals were newly developed and synthesized by wet chemical precipitation process. The result demonstrated that polyethyleneglycol (PEG) spacer arm and HA targeting moiety were successfully immobilization on the surface of MHAP. Moreover, it possessed relatively good biocompatibility and superparamagnetic property. In summary, HA-modified MHAP could not only be localized in site, but also generating heat within applied external magnetic field.
    Advisor Committee
  • Hsi-Chin Wu - advisor
  • Feng-Huei Lin - co-chair
  • Hong-Ming Lin - co-chair
  • Files indicate in-campus access at 5 years and off-campus not accessible
    Date of Defense 2012-07-19 Date of Submission 2012-08-21


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