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Title page for etd-0830107-154322


URN etd-0830107-154322 Statistics This thesis had been viewed 2734 times. Download 1076 times.
Author Chi-Tai Huang
Author's Email Address No Public.
Department Chemical Engineering
Year 2006 Semester 2
Degree Master Type of Document Master's Thesis
Language English Page Count 125
Title STUDIES ON PREPARATION AND PROPERTIES AND APPLICATION OF THE N-ISOPROPYLAMIDE AND GLYCIDY METHACRYLATE COPOLYMERIC HYDROGEL
Keyword
  • hydrogel
  • copolymer
  • copolymer
  • hydrogel
  • Abstract Abstract
    Part 1
    Studies on Preparation and Properties of poly(NIPAAm-co-GMA) and poly(NIPAAm-co-GMA-co-DMA) Copolymeric Hydrogels
    In this study we synthesized two series of reversible thermo-responsive hydrogel, poly (NIPAAm-co-GMA) and poly(NIPAAm-co-GMA-co-DMA) , The effect of the different monomer ratios of the poly(NIPAAm/GMA) and poly(GMA/DMA) copolymeric hydrogel on the swelling behaviors and physical properties was investigated. The result showed that the swelling ratio in deionized water increased with an decrease of content of GMA in the copolymeric hydrogel. The compressive modulus、crosslink denity and mechanical strength increased with GMA content in the copolymeric hydrogel.
      The influence of the copolymeric composition on the drug release behavior in the poly(NIPAAm-GMA ) and poly(NIPAAm-GMA-DMA) hydrogel which were investigated in this study. The loading amount of sulfanilamide increase with an increase of content of GMA in the gel,but the release ratio was affected by the swelling ratio of the gel in the deionized water .
    Abstract
    Part 2
     A series of pH/thermo-sensitivity hydrogels, were prepared from N-isopropylacrylamide (NIPAAm) , acrylic acid (AA), and glycidyl methacrylate (GMA), crosslinked with N,N-methylenebisacrylamide (NMBA) . The effect of the different monomer ratios of GMA and AA in the copolymeric hydrogel on the swelling behaviors and physical properties were investigated. The result showed that the swelling ratio in deionized water and in phosphate buffer solution increased with an increase of content of AA in the copolymeric hydrogel. The compressive modulus,crosslinking density and mechanical strength decreased with an increase of AA content in the copolymeric hydrogel.
      The influence of the copolymeric composition on the drug release behavior in the poly(NIPAAm-co-GMA-co-AA ) hydrogel was also investigated in this study. The loading amount of sulfanilamide increase with an increase of content of GMA in the gel,but the release ratio was affected by the swelling ratio of the gel in the deionized water
    Abstract
    Part 3
       Three series of thermo-responsive hydrogel, was synthesized from N-isopropylacrylamide (NIPAAm) , glycidyl methacrylate (GMA), and N,N-dimethylacryamide (DMA) or acrylic acid (AA) . The effect of the different monomer ratios of GMA and DMA or GMA and AA in the copolymeric hydrogel on the swelling behaviors and physical properties were investigated. The result showed that the swelling ratio in deionized water increased with an increase of content of NIPAAm 、DMA and AA in the copolymeric hydrogel. The compressive modulus,crosslink density and mechanical strength increased withGMA content in the copolymeric hydrogel.
      The influence of the copolymeric composition on the Immobilized enzyme in the poly(NIPAAm-co-GMA), poly(NIPAAm-co-GMA-co-DMA), and poly(NIPAAm-co-GMA-co-AA) copolymeric hydrogels which was used as a support to immobilize trypsin was investigated. The result showed that the copolymeric hydrogel showed a good immobilized capacity of trypsin. The immobilized trypsin as a ligand of affinity chromatography had 54 , 53, and 35 percent activity of trypsin inhibitor in the crude extract of sweet potato can be recovered by affinity chromatography. The molecular weights of the purified trypsin inhibitors are more than 20 KDa by SDS-PAGE.
    Advisor Committee
  • Wen-Fu Lee - advisor
  • Der-Jang Liaw - co-chair
  • Files indicate in-campus access at 3 years and off-campus access at 3 years
    Date of Defense 2007-07-31 Date of Submission 2007-08-30


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