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URN etd-0831111-174941 Statistics This thesis had been viewed 3272 times. Download 5201 times. Author Chia-wen Cheng Author's Email Address No Public. Department Bioengineering Year 2010 Semester 2 Degree Master Type of Document Master's Thesis Language zh-TW.Big5 Chinese Page Count 58 Title Properties of Microemulsion Containing 3-O-Ethyl Ascorbic Acid Keyword 3-O-Ethyl Ascorbic Acid Ascorbic Acid Microemulsion Percutaneous penetration Percutaneous penetration Microemulsion Ascorbic Acid 3-O-Ethyl Ascorbic Acid Abstract Microemulsion is easy to prepare with high stability, and enhance the bioavailability. The properties of micoremulsion containing vitamin C and 3-o-ethyl ascorbic acid respectively, including pH, viscosity, mean particle diameter, refractive index during storage were determined in this study. In vitro transdermal penetration of 3-o-ethyl ascorbic acid in microemulsion was also compared with conventional emulsion. The results showed that pH of microemulsion with 3-o-ethyl ascorbic acid
reduced at 45℃. However, changes in viscosity, mean particle diameter, refractive index of micoremulsion containing vitamin C and 3-o-ethyl ascorbic acid were not found during storage at 25 and 45℃. It was noted that the content of vitamin C in microemulsion decreased from 1.98% to ca. zero after storage for 79 d at 25 and 45℃. On the other hand, the content of 3-o-ethyl ascorbic acid was similar during storage. Transdermal penetration of 3-o-ethyl ascorbic acid in microemulsion was higher than that in conventional emulsion.
Advisor Committee Shiow-Ling Lee - advisor
Cheng-Chun Chou - co-chair
I-Ching Kuan - co-chair
Files Date of Defense 2011-07-29 Date of Submission 2011-08-31