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The defense date of the thesis is 2012-09-07
The current date is 2018-11-20
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URN etd-0906112-150728 Statistics This thesis had been viewed 1481 times. Download 0 times. Author Yu-sheng Chen Author's Email Address No Public. Department Bioengineering Year 2011 Semester 2 Degree Master Type of Document Master's Thesis Language zh-TW.Big5 Chinese Page Count 77 Title Surface Acoustic Wave and Molecularly Imprinted Polymer
Chip of Creatine Kinase-MM and Microchannels
Keyword creatine kinase microfluidic surface acoustic wave devices interdigital transducers molecularly imprinted polymers molecularly imprinted polymers interdigital transducers surface acoustic wave devices microfluidic creatine kinase Abstract We use a MEMS process to manufacture microfluidic separation chip, which is used for the pre-treatment of sample containing creatine kinase. The microfluidic chip is made of poly - dimethylsiloxane ( PDMS ). We also develop a surface modification process using the combination of oxygen plasma to extend the hydrophilicity of the PDMS material. After injection of the micro-biological samples, the microfluidic chip drives the magnetic material, such as red blood cells, to separate channel, which may reduce the interferences resulting from of those materials.
Surface acoustic wave chip was made with lithium tantalite. The interdigital transducers with a width of 5 μm and a thickness of 75 nm were made with lithography technology on lithium tantalite. Creatine kinase molecules were used as template and a molecular imprinting film was prepared on the surface acoustic wave device. The holes on the molecular imprinting film are able to recognize creatine kinase. A network analyzer instrument was used to detect the changes of center frequency of surface acoustic wave when binding and re-binding of creatine kinase. The frequency changes corresponding to the concentration of creatine kinase were discussed.
Advisor Committee Chung-yih Wang - advisor
none - co-chair
none - co-chair
Files Date of Defense 2012-07-23 Date of Submission 2012-09-07