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URN etd-0907112-141324 Statistics This thesis had been viewed 1237 times. Download 1 times. Author Kun-Ming Chen Author's Email Address No Public. Department Chemical Engineering Year 2011 Semester 2 Degree Master Type of Document Master's Thesis Language English Page Count 121 Title Studies on Synthesis and Application of Multi-arm Thermosensitive Biodegradable Materials Derived from Polyols Keyword sol-gel PLGA glycolide lactide pentaerythritol pentaerythritol lactide glycolide PLGA sol-gel Abstract A novel four-arm biodegradable PTOL-(PLGA)4 compound (I) was prepared from pentaerythritol (PTOL) as initiator, stannous octoate Sn(Oct)2 as catalyst, glycolide (GA), and lactide (LA) by ring-opening polymerization. In order to synthesize four-arm [PTOL-(PLGA- mPEG)4], poly(ethylene glycol) monomethyl ether (mPEG) was modified to mPEG carboxylic acid (mPEGacid) at first. Then, the synthesis of [PTOL-(PLGA- mPEG)4] was carried out by esterification reaction with PTOL-(PLGA)4 and mPEGacid. The effect of different hydrophilic and hydrophobic segments of the four-arm [PTOL-(PLGA- mPEG)4] on the phase diagram of gel formation under various polymer concentrations by rheometer and tube turn over methods was investigated.
The results showed that with an increase of the concentration of polymers, the temperature transferred from sol to gel decrease, but the temperature transferred from gel to precipitate phase increase. In addition, the temperature transferred from gel to precipitate phase can be increased under 1000ppm BSA solution.
Advisor Committee Wen-Fu Lee - advisor
Chi-Yuan Huang - co-chair
Hong-Ru Lin - co-chair
Files Date of Defense 2012-07-30 Date of Submission 2012-09-07