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URN etd-0909110-150351 Statistics This thesis had been viewed 3357 times. Download 2023 times. Author Wei Chen Author's Email Address No Public. Department Materials Engineering Year 2009 Semester 2 Degree Master Type of Document Master's Thesis Language zh-TW.Big5 Chinese Page Count 93 Title Immobilization of poly(acrylic acid) by using plasma treatment and UV-induced polymerization then immobilization Chitosan / Alginate mixed solution on the 316L stainless steel. Keyword chitosan surface polymerization plasma polymerization alginate sensitive hydrogel sensitive hydrogel alginate plasma polymerization surface polymerization chitosan Abstract The stainless steel is one kinds of an inorganic material, it`s difficult to immobile the polymer due to its metallic properties. In this study, using plasma treatment to deposit an interface layer, then using UV-induced polymerization to form poly(acrylic acid) hydrogel. It could be used in drug delivery system which is one kinds of pH sensitive hydrogel, and it could be deposited a layer of HMDSZ film to stem drug released. Then immerse into EDC/NHS solution to immobile chitosan and alginate on the surface which suitable for cell adhesion.
The surface wettability will become hydrophile after UV-induced polymerization.It is contributive of chitosan immobilization. Then the amount of chitosan by using acrylic acid immobilization is about 2.08mg/cm2, it is much higher than which is only by surface activation production about 0.24mg/cm2. Besides, the effect of amount of chitosan/alginate mixed solution was followed by alginate ratio increase. As the result of increasing the alginate ratio will favorable for surface immobilization.
The results indicate that plasma deposited HMDSZ film can suspend swelling ratio of poly(acrylic acid) from 43~47 to 25~30 ratio, but in the drug release system is not significantly.
Advisor Committee Ko-Shao Chen - advisor
Feng-Huei Lin - co-chair
Hsi-Chin Wu - co-chair
Jen-Ming Yang - co-chair
Files Date of Defense 2010-07-02 Date of Submission 2010-09-13