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Title page for etd-0909114-172853


URN etd-0909114-172853 Statistics This thesis had been viewed 1111 times. Download 0 times.
Author Chia-yu Hu
Author's Email Address No Public.
Department Bioengineering
Year 2013 Semester 2
Degree Master Type of Document Master's Thesis
Language zh-TW.Big5 Chinese Page Count 73
Title PROTECTIVE EFFECTS OF MIMOSA PUDICA AGAINST UVB-INDUCED DAMAGE OF HUMAN KERATINOCYTES
Keyword
  • Mimosa pudica
  • skin photoaging
  • ultraviolet radiation
  • HaCaT cells
  • HaCaT cells
  • ultraviolet radiation
  • skin photoaging
  • Mimosa pudica
  • Abstract Recently herbal medicines have gained an increased interest in their functional properties. Mimosa pudica, rich in polyphenolic compounds, showed high antioxidant activities and inhibitory melanogenesis. In this work, the protective effects of M. pudica methanolic extract (MPME) and M. pudica hot water extract (MPWE) against ultraviolet B (UVB) - induced damage in a human keratinocytes were evaluated. MPME and MPWE showed low cytotoxicities to HaCaT cells. With increasing UVB radiation dose, viability of HaCaT cells deceased significantly (p <0.05), increasing a high degree of damage on HaCaT cells with UVB. After irradiation with 25, 50 and 100 mJ/cm2, respectively, HaCaT cells pretreated with M. pudica showed high viability compared to those without M. pudica extracts treatments. MPME exhibited significantly better protective effect than MPWE (p <0.05). In addition, M. pudica decreased radical oxygen species generation and lipid peroxides level induced by UVB irradiation in HaCaT cells. M. pudica restored glutathione contents reduced by UVB exposure at 25mJ/cm2. These results suggested that M. pudica showed a protective effect to UVB- induced damaged in keratinocytes.
    Advisor Committee
  • Shiow-ling Lee - advisor
  • Chi-yang Yu - co-chair
  • Chwen-jen Shieh - co-chair
  • Files indicate in-campus access at 5 years and off-campus access at 5 years
    Date of Defense 2014-07-31 Date of Submission 2014-09-10


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