Berberine, a common alkaloid of isoquinoline alkaloids, can be obtained not only through extraction from Coptis chinensis, Phellodendron amurense, and Radix Berberidis, but also from chemical synthesis. Berberine was used in treatments for diarrhea and enteritis, but recently pharmacological studies confirmed that Berberine has obvious effect of lowering insulin-resistance, cholesterol, and heart failure, and also proved that Berberine is an excellent agent for anti-arrhythmic, anti-inflammatory, anti-platelet, and anti-proliferation of vascular smooth muscle cells. This study compared the six kinds of process methods producing Berberine, and also simulated the commercial production process to identify the most economically beneficial production model. The simulation results shown the best case was the extraction method from Coptis chinensis of 5,532 kg/year. The production cost of berberine was estimated as 571 NT $/kg. The annuals gross-profit was 6,245,000 NT$. Although the highest Berberine content was from Coptis chinensis, which is slow growth and less sources, therefore most of the commercial production of Berberine was the extraction from Radix Berberidis.
Key words: Berberine, Berberine hydrochloride, Radix berberidis, Phellodendron amurense, Coptis chinensis, Economic benefits.